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 CNSI ALMS/MSI Facilities

 

Welcome to the Homepage of the UCLA CNSI Advanced Light Microscopy/Spectroscopy (ALMS) and Macroscale Imaging Facilities (MSI). 

The ALMS Facility is located in the basement of the CNSI Building in room B145.  The MSI Facility is in room 2144.  The facilities are primarily self-service and are open to all classes of users academic and industrial.  Training is provided for all instruments after which users are given 24 hour a day, 7 day a week access to the instruments.  To get started using the facility, please go to: Becoming a UserTo contact us, please send an E-mail to: alms@cnsi.ucla.edu.

If you wish to sign up for an account or if you are already a user of the ALMS or MSI and wish to reserve time on one of the instruments, please go to the CNSI Core Lab Management System.

Using the ALMS/MSI Facility requires that you follow certain policies and guidelines that are listed in the Requirements page.

 

Mission


The mission of the facilities is to provide consultation, services and support for the application of novel microscopic and spectroscopic methods and advanced image analysis techniques for the study of macromolecules, cellular dynamics and nano-scale characterization of bio-materials. The facility provides a collection of high-level, customized biological fluorescence microscopes and small-animal imaging devices that provide the ability to study biological processes with high spatial and temporal resolution in whole organisms and in living cells down to the single molecule detection level with nanometer-accuracy. Located on the basement and second floors of the CNSI building, two optical suites of 1,000 square feet each were specifically designed to house our microscopes with the required environment control (low vibration, air-filtered, air-conditioned to 1C and light-tight) and services. The facility currently provides the following services:  Wide-field Fluorescence Imaging Microscopy (on a limited basis), Confocal One-Photon and Two-Photon Laser Scanning Microscopy, (both point scanning and spinning disk), Fluorescence Correlation Spectroscopy (FCS), Fluorescence Resonance Energy Transfer (FRET), microscopic and macroscopic Fluorescence Lifetime Imaging (FLIM) with Time-Correlated-Single-Photon-Counting (TCSPC) and Near-Infrared (NIR) Detection, Stimulated Emission Depletion laser-scanning microscopy (STED) (a super-resolution technique), both microscopic and macroscopic (small animal) spectral unmixing and laser capture microdissection.